Ameloblastic carcinomasecondary type, a rare case report and. Metastasizing ameloblastoma is defined as an ameloblastoma. Ameloblastoma is the most common odontogenic tumor, but the incidence of its metastasis is extremely low. We report a case of recurrent ameloblastoma metastasizing to the cervical lymph node.
Ameloblastoma can show up either in a regular xray or in an mri imaging study. Ameloblastoma followed by metastatic ameloblastoma and finally ameloblastic carcinoma primary and metastatic lesions were confirmed by xray, computed tomography ct and pathological examination. Moreover, there is a type of ameloblastoma known as metastasizing ameloblastoma or ameloblastic. It is difficult to predict metastasis, even with adequate treatment of the primary lesion. According to the new criteria, the histological and clinical features of ma are more homogenous. As for non metastasizing ameloblastoma, the majority of cases were localized in the mandible 9. Doubling time of ameloblastoma metastasizing to the lung. There is no standard protocol to prevent or detect metastatic ameloblastoma.
In 1885, malassez introduced the name adamantinoma. Alternatively, you can download the file locally and open with any standalone pdf reader. Mar 31, 2016 here, metastasizing ameloblastoma is defined as an ameloblastoma that metastasize in spite of a benign histology. Various treatment algorithms for ameloblastoma have been reported. Pdf unicystic ameloblastoma metastasizing to multiple. The typical who description of a metastasiz ing malignant ameloblastoma is an ameloblastoma that metastasizes in spite of a benign histological appearance 9. Malignant ameloblastoma metastasis to the neck core. It has a tendency to be more aggressive than the other types and has a higher incidence of recurrence. Ameloblastoma can resemble, both in behavior and structure, the common basal cell carcinoma,2 and although it is locally invasive and has a high recurrence. Apr 30, 2015 ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser.
Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency towards recurrence. Report of a case with molecular characterization matteo rotellini1, giandomenico maggiore2, massimo trovati2, massimo squadrelli saraceno2, alessandro franchi1 1department of surgery and translational medicine, section of anatomic pathology, university of florence, italy. Jun 25, 2019 leave a comment on ameloblastoma histopathology pdf ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Apr 19, 2016 ameloblastoma is a rare, noncancerous benign tumor that typically develops in the jaw near the molars.
Ameloblastomas are locally invasive tumours of odontogenic origin with a high propensity for local recurrence. Metastasizing granular cell type ameloblastoma with. Ameloblastoma genetic and rare diseases information. It originates in the cells that form the enamel that protects your teeth. Malignant ameloblastoma metastasis to the neck radiological. Molecular etiopathogenesis of ameloblastoma current. Ameloblastoma is a rare, noncancerous benign tumor that typically develops in the jaw near the molars. Ameloblastoma, from the english word amel which means enamel and the greek word blastos which means germ, is a rare entity of benign odontogenic tumor. Here, metastasizing ameloblastoma is defined as an ameloblastoma that metastasize in spite of a benign histology. Pdf ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior.
Egfr, cd10 and proliferation marker ki67 expression in. Malignant ameloblastoma metastatic ameloblastoma in the lung. As for nonmetastasizing ameloblastoma, the majority of cases were localized in. This is the first case report of unicystic ameloblastoma metastasizing to the cervical lymph nodes. However, the term adamantinoma has been applied in the past to ameloblastomas of the jaw, including several cases with reported metastasis, and therefore. Metastatic ameloblastoma responding to combination. Segmental mandibulectomy along with cervical lymph node dissection was performed. However, ameloblastoma is unrelated histologically to adamantinoma of the bone, and this terminology should be abandoned to avoid confusion. It is a benign neoplasm but local recurrence is common. It develops in the soft tissue of the gingiva and mucosa. When metastases occur, which are uncommon, lungs constitute the most frequent site involved. However, recurrences have been noted for more than 10 years after the initial treatment 6. Differential diagnosis of conventional multicystic ameloblastoma malignant ameloblastoma also called metastasizing ameloblastoma identical histology but with metastasis ameloblastic carcinoma variable features of amelobastoma. Ameloblastoma genetic and rare diseases information center.
This is the first reported case presenting a perineural spread of metastasis in ameloblastoma. Ameloblastoma is a rare benign odontogenic tumor with locally aggressive behavior and a high recurrence rate. Fineneedle aspiration biopsy of ameloblastic carcinoma of the mandible. This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the french physician louischarles malassez. In this study the 40years single institution experience with the management of primary ameloblastoma will be reported and discussed in relation to the present concepts of this odontogenic tumour. Bronchoscopically treated endobronchial ameloblastoma with. Ameloblastoma is a benign odontogenic tumour that may exhibit aggressive biological behaviour with local recurrence and metastasis following. We presented a case of malignant ameloblastoma of the mandible with neck metastasis.
It arises from the epithelium of the dental lamina and it is known by its local aggressive behavior and the high recurrence rate. We report a case of maxillary ameloblastoma with development of neck and brain metastases after repeated local recurrences. The following data were gathered for reports that demonstrated welldifferentiated ameloblastoma at the metastatic site. Department of oral and maxillofacial surgery, hitkarini dental college and hospital, jabalpur, madhya pradesh, india. Ameloblastoma is a benign odontogenic tumour that may exhibit aggressive biological behaviour with local recurrence and metastasis following initial surgical resection. Jan 08, 2015 clinical presentation in the early stages. Ameloblastoma is the second most common benign odontogenic tumour shafer et al. Pdf ameloblastoma is a rare odontogenic tumor of the jaw. Radiologically, it manifests itself in the form of uni or multicystic intrabony expansive lesions, with destruction of the medullary zone of the existing bone. Malignant ameloblastomas are different from ameloblastic carcinomas. Ameloblastoma, a semibenign odontogenic tumor, is divided into four subtypes based on the clinical presentation, radiological manifestations and histological characteristics. The management of metastasizing ameloblastoma has been only surgical treatment, and cervical lymph nodes metastasis of ameloblastoma is to be treated by some type of a neck dissection.
We report a patient who was diagnosed with ameloblastoma of the maxilla 6 years ago and had undertaken the operation. Peripheral ameloblastoma peripheral ameloblastoma is a uncommonrare type of odontogenic tumor. Ameloblastoma of the maxilla is a rare odontogenic tumor that rarely metastasizes. The median survival time after metastasis is 2 years. Ameloblastic carcinomasecondary type, a rare case report and distinction from malignant ameloblastoma rajesh b dhirawani, sumit asrani, anshalika agrawal, sauvik singha and kshitij aggarwal. Clinical and radiologic behaviour of ameloblastoma in 4 cases.
This study was carried out on 22 retrospective cases of mandibular ameloblastoma from the period from jan 2002 to jan 2008 with follow up period until jan 2011 3 to 8 years follow up peroid. Malignant ameloblastomas are tumors considered metastatic despite the appearance of welldifferentiated or benign histology. Abstract we report here a case of ameloblastoma of the mandible with multiple local recurrences and metastasis to the orbit. Ameloblastoma is generally considered to be a benign tumor of the odontogenic epithelium. This occurrence is estimated in approximately 2% of the cases 4, and the most common site for metastasis is the lung 75 80% 5, followed by the cervical lymph nodes, the diaphragm, the liver and the brain. Plexiform ameloblastoma does not have prominent palisading. We report a case of unicystic ameloblastoma metastasizing to the cervical lymph nodes. Ameloblastoma is divided into 3 clinicoradiologic groups. Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium ameloblasts, or outside portion, of the teeth during development much more commonly appearing in the lower jaw than the upper jaw. Ameloblastoma is a benign but locally aggressive epithelial odontogenic neoplasm. This patient presented with a radiolucent cystic lesion in the left mandibular region.
Here, we report three cases of histologically confirmed pulmonary ma. In many cases, the first sign is painless swelling in the jaw. Request pdf metastasizing ameloblastoma ameloblastomas are locally invasive tumours of odontogenic origin with a high propensity for local recurrence. Ameloblastoma was first described in 1827 by cusack. Kattimani v, sumanti j, prasad lk 2015 granular cell ameloblastoma. Pdf ameloblastoma is a rare lowgrade odontogenic tumor of epithelial origin. Metastasizing ameloblastoma is a rare tumor and it is renowned for appearing in approximately 2% to 5% of cases 12. The condition most often occurs in adults in their 30s and 40s, though it can occur at any age. Metastatic malignant ameloblastoma responding to chemotherapy.
Rakesh s ramesh,suraj manjunath,tanveer h ustad,saira pais and k shivkumar. This might be due to the fact that some authors do not. C ratio, increased mitoses with atypical forms, necrosis can also metastasize ameloblastic fibroma. Malignant ameloblastoma metastatic ameloblastoma in the. The world health organization who has defined malignant. Malignant ameloblastoma metastatic ameloblastoma, ma is currently defined as a distinct pathologic entity, ma, despite its histologically benign appearance. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. The incidence of ameloblastomas is estimated at 0,5 per million population per year, although in some parts in the world, amelpblastoma. Jul 25, 2015 malignant ameloblastoma metastatic ameloblastoma, ma is currently defined as a distinct pathologic entity, ma, despite its histologically benign appearance. Surgical removal of the affected tissue is the preferred treatment. This is the case of a 74yearold man with left mandibular granular cell type ameloblastoma diagnosed in 1978.
It is estimated that 2% to 5% of ameloblastomas metastasize to regional lymph nodes and distant sites with. A case of ameloblastoma with extensive pulmonary metastasis. Metastasizing ameloblastoma metastasizing ameloblastoma laughlin, edward h. Studying the role played by egfr, cd10 and ki67 in the recurrence of ameloblastoma. As for nonmetastasizing ameloblastoma, the majority of cases were localized in the mandible 9. We report an unusual case of metastatic ameloblastoma. In 80% of cases, it is localized in the mandibular molar and ascending ramus area, mostly associated with an unerupted tooth. Odontogenic tumour, ameloblastoma, ameloblastoma unicystic, ameloblastoma solid, ameloblastoma multicystic. The mandible is the most common site of occurrence for both ameloblastic carcinoma types. Two of the three patients complained of chest pain as the. Metastasizing ameloblastoma international journal of oral and.
Pdf rare case of ameloblastoma with pulmonary metastases. They have a high tendency to recur, but a low incidence of metastasis. Unicystic ameloblastoma metastasizing to multiple cervical. Surgery is the most acceptable modality of treatment, even if a biological approach is currently on study. The solid ameloblastoma is the most common form of the lesion 86%. Because of that reason, the clinical not histological finding could be of great importance for diagnosis of metastasizing ameloblastoma. Ameloblastoma nord national organization for rare disorders. It occurs over a wide range of ages mean age is in the 20s or 30s and with. Metastasizing ameloblastoma philippine journal of otolaryngology. In this paper, a case of aot in the anterior maxillary region associated with a permanent lateral incisor will be reported. Ameloblastoma free download as powerpoint presentation. Two of the three patients complained of chest pain as the primary.
Ameloblastic carcinomasecondary type, a rare case report. Ameloblastoma is the most common odontogenic tumor, but the incidence of its metastasis is low. Jun 24, 2014 peripheral ameloblastoma peripheral ameloblastoma is a uncommonrare type of odontogenic tumor. The patient was a 63yearold japanese woman with visual disturbance of her right eye. The patient was a 63yearold japanese woman with visual disturbance of. Leave a comment on ameloblastoma histopathology pdf ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Ameloblastoma is a rare disorder that affects males and females in equal numbers. Ameloblastoma and its malignant transformation ijcmr. It affects persons of all ethnic backgrounds and of all age groups.
Robinson y martinez son quienes describen por primera vez al au como una entidad distinta por presentar cuadros. Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. Jaw extended resection, neck dissection, radiation and. The preferred treatment of ameloblastoma is wide surgical removal with the possible exception for unicystic ameloblastoma, as will be discussed later.
186 1283 467 66 1037 1060 794 1158 1057 326 902 774 261 658 413 1066 1346 816 265 852 885 924 568 741 1464 1121 1445 500 1363 164 297 976 736 783 1073 68 594 1251 648 487 615 317 71